Potomac Affinity Proteins, LLC

Our approach to protease engineering is to create simple components that can be assembled into more complex, multi-component enzymatic machines. Simple components, once fully characterized, can be combined to form switches, signal amplifiers, and transducers. Proteases are particularly useful to incorporate into enzymatic machines because, in addition to generating optical signals, they can also modify other proteins in reaction cascades. Analogous to sophisticated electronic devices built from standard components, an enormous potential exists for creating enzymatic machines that link diverse enzymatic function.